The human skeleton’s unique adaptations relied on gene regulatory changes

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02775-z Variants in genes involved in the production of extracellular matrix molecules could have enabled the skeletal adaptations that distinguish humans from other great apes.

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The gene-regulatory evolution of the human skeleton

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The human skeleton’s unique adaptations relied on gene regulatory changes

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The human skeleton’s unique adaptations relied on gene regulatory changes | Slantwise